Treatment of mesothelioma with gene-modified PA1STK cells and ganciclovir: a...
Like a Trojan Horse, the genetically modified cells enter the pleural space but carry the seeds of destruction. This article presents the results in humans of the first intrapleural instillation of a...
View ArticleTGF-beta signaling and defects in the NF2-Hippo pathway cooperate to promote...
A recent publication by Sekido and colleagues has highlighted the connection between two relevant survival/growth pathways in mesothelioma, TGF-beta and NF2/Hippo. TGF-beta may play important roles in...
View ArticleSerum mesothelin for diagnosing malignant pleural mesothelioma
A Forest plot of the sensitivity of serum mesothelin at a common diagnostic threshold of 2.00 nmol/L displays the heterogeneity among the different studies. Mesothelin is currently considered the best...
View ArticleMARF 2012 Grant Program – Call for Applications
The Mesothelioma Applied Research Foundation is calling for applications for its 2012 round of mesothelioma research grant funding. Continuing its efforts to stimulate translational research for the...
View ArticleGuidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of...
For mesothelioma (two panels on left), immunohistochemical stains for calretinin (top) and cytokeratin 5/6 (bottom) are diffuse and strong. This differentiates mesothelioma from lung cancer; for two...
View ArticleEarly detection of malignant pleural mesothelioma in asbestos-exposed...
Distribution of the 13 protein biomarkers by pathologic stage. Early detection of mesothelioma is key for chemo-efficiency. The authors conducted a multi-center case-control studies in serum from 117...
View ArticleSequential Binary Gene-Ratio: a novel molecular diagnostic strategy
Though long considered the gold-standard for diagnosing cancer, customary pathological approaches are not always successful. Here, De Rienzo and colleagues applied the bioinformatic technique of...
View ArticleA new way of looking at cancer is on its way
The progression and evolution of cancer genomics is giving us unprecedented insight into malignancies. Most recently, a paper on acute myeloid leukemia and one on endometrial carcinoma, part of an...
View ArticleAnnals of Cardiothoracic Surgery: Mesothelioma
Many leading investigators have contributed to the November 2012 issue of Annals Of Cardiothoracic Surgery to provide an overview of the state of the art in translational research and clinical care in...
View ArticleAn Anti-CTLA4 antibody may be effective in malignant mesothelioma
Recent studies have indicated that tumor-specific immune responses may be activated in patients with malignant mesothelioma, suggesting that inhibition of the immunosuppressive receptor cytotoxic...
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